GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs12960119 | 1 | rs9948342 | chr18:23699545 | SS18 | chr18:23596219-23671164:- | 0.27 | 3.42 | 0.00067 | Rhegmatogenous retinal detachment |
| THCA | cis | rs12960119 | 1 | rs9950515 | chr18:23736634 | SS18 | chr18:23596219-23671164:- | 0.28 | 3.51 | 0.000493 | Rhegmatogenous retinal detachment |
| THCA | cis | rs12960119 | 1 | rs9952498 | chr18:23728300 | SS18 | chr18:23596219-23671164:- | 0.28 | 3.51 | 0.000493 | Rhegmatogenous retinal detachment |
| THCA | cis | rs11874381 | 1 | rs9955622 | chr18:47203955 | CXXC1 | chr18:47808715-47814692:- | 0.09 | 3.34 | 0.000897 | C-reactive protein levels or HDL-cholesterol levels (pleiotropy) |
| THCA | cis | rs12960119 | 1 | rs9956068 | chr18:23584823 | SS18 | chr18:23596219-23671164:- | 0.26 | 3.4 | 0.000737 | Rhegmatogenous retinal detachment |
| THCA | cis | rs7226229 | 1 | rs996065 | chr17:20936403 | USP22 | chr17:20902908-20947073:- | -0.18 | -3.83 | 0.000146 | Blood trace element (Se levels) |
| THCA | cis | rs12960119 | 1 | rs9962034 | chr18:23601153 | SS18 | chr18:23596219-23671164:- | 0.27 | 3.42 | 0.000688 | Rhegmatogenous retinal detachment |
| THCA | cis | rs9963862 | 1 | rs9963862 | chr18:20587911 | NPC1 | chr18:21108363-21166581:- | -0.11 | -3.44 | 0.000637 | Late-onset myasthenia gravis |
| THCA | cis | rs12960119 | 1 | rs9967283 | chr18:23720885 | SS18 | chr18:23596219-23671164:- | 0.28 | 3.54 | 0.000435 | Rhegmatogenous retinal detachment |
| THCA | cis | rs10935120 | 1 | rs9968172 | chr3:134231251 | ANAPC13 | chr3:134196547-134204865:- | -0.4 | -12.79 | 2.04E-32 | Height |
| THCA | cis | rs10935120 | 1 | rs9968172 | chr3:134231251 | CEP63 | chr3:134204575-134293852:+ | -0.29 | -6.33 | 5.73E-10 | Height |
| THCA | cis | rs4765219 | 1 | rs9971695 | chr12:124413491 | DNAH10 | chr12:124247042-124420265:+ | 0.19 | 3.77 | 0.000184 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs4765219 | 1 | rs9971695 | chr12:124413491 | ZNF664 | chr12:124457670-124499967:+ | -0.16 | -4.41 | 1.29E-5 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs997295 | 1 | rs997295 | chr15:68016343 | C15orf61 | chr15:67813522-67819638:+ | 0.12 | 3.38 | 0.000791 | Motion sickness |
| THCA | cis | rs997295 | 1 | rs997295 | chr15:68016343 | IQCH | chr15:67547188-67794139:+ | 0.17 | 5.24 | 2.46E-7 | Motion sickness |